Find NARCAN® Nasal Spray

INDICATIONS AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up.

NARCAN® Nasal Spray is safe and effective in children for known or suspected opioid overdose.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines. Always carry NARCAN® Nasal Spray with you in case of an opioid emergency.

  1. Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:
    • unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • the black circle in the center of the colored part of the eye (pupil) is very small, sometimes called "pinpoint pupils" in someone difficult to awaken
  2. Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® Nasal Spray before an opioid emergency happens.
  3. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.
  4. The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person until emergency help is received.

Who should not use NARCAN® Nasal Spray?

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What should I tell my healthcare provider before using NARCAN® Nasal Spray?

Before using NARCAN® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • are pregnant or plan to become pregnant. Use of NARCAN® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use NARCAN® Nasal Spray.
  • are breastfeeding or plan to breastfeed. It is not known if NARCAN® Nasal Spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NARCAN® Nasal Spray?

NARCAN® Nasal Spray may cause serious side effects, including:
Sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving NARCAN® Nasal Spray and may include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increase blood pressure.

In infants under 4-weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.

The risk information provided here is not comprehensive. To learn more, talk about NARCAN® Nasal Spray with your health care provider or pharmacist. The FDA-approved product labeling can be found here or 1-844-4NARCAN (1-844-462-7226).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including the Patient Information, for NARCAN® Nasal Spray.

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MORE QUESTIONS?

Find answers to the most frequently asked questions about NARCAN® Nasal Spray.

For Patients, Family, Friends, Caregivers

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines. Always carry NARCAN® Nasal Spray with you in case of an opioid emergency.

  1. Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:
    • Unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • Breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • The black circle in the center of the colored part of the eye (pupil) is very small, sometimes called “pinpoint pupils,” in someone who is difficult to awaken
  2. Family members, caregivers or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® before an opioid emergency happens.
  3. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency help.
  4. The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes in the alternate nostril using a new NARCAN® Nasal Spray and watch the person closely until emergency help is received.
What is NARCAN® Nasal Spray?

NARCAN® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up because they may relapse into breathing difficulty.

NARCAN® Nasal Spray is safe and effective in children for known or suspected opioid overdose.

When should NARCAN® Nasal Spray be used?

Use NARCAN® Nasal Spray right away if you think there are signs of an opioid overdose emergency.

Signs of an opioid overdose may include:

  • Unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
  • Breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
  • The black circle in the center of the colored part of the eye (pupil) is very small, sometimes called “pinpoint pupils,” in someone difficult to awaken

Get emergency medical help right away in any cases of known or suspected overdose. NARCAN® Nasal Spray is not a substitute for emergency medical care. Administer in accordance with the Instructions for Use.

Who should not use NARCAN® Nasal Spray?

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride (HCl) or any of the ingredients in NARCAN® Nasal Spray, which include:

  • Benzalkonium chloride (preservative)
  • Disodium ethylenediaminetetraacetate (stabilizer)
  • Sodium chloride
  • Hydrochloric acid (to adjust pH)
  • Purified water

Use in infants with extreme caution. Please see Important Safety Information and Full Prescribing Information.

How should I use NARCAN® Nasal Spray?

Read the “Instructions for Use” at the end of the Patient Information leaflet for detailed information about the right way to use NARCAN® Nasal Spray.

  • Use NARCAN® Nasal Spray exactly as prescribed by your healthcare provider.
  • Each NARCAN® Nasal Spray contains only 1 dose of medicine and cannot be reused.
  • Lay the person on their back. Support their neck with your hand and allow the head to tilt back before giving NARCAN® Nasal Spray.
  • NARCAN® Nasal Spray should be given into one nostril.

If additional doses are needed, give NARCAN® Nasal Spray in the other nostril.

Does NARCAN® Nasal Spray only work in the nose?

Yes, NARCAN® Nasal Spray is for intranasal (in the nose/nostril) use only.

Before I use NARCAN® Nasal Spray, do I need training? Do I need to assemble NARCAN® Nasal Spray or measure the medicine?

There is no special training, measuring or assembly required to use NARCAN® Nasal Spray. NARCAN® Nasal Spray comes as a ready-to-use device that contains a single, pre-filled, pre-measured dose of naloxone.

NARCAN® Nasal Spray should be used in accordance with the Instructions for Use contained in the Full Prescribing Information. The caregiver should familiarize her/himself with these instructions in order to be sure to administer NARCAN® Nasal Spray properly.

Can I give myself NARCAN® Nasal Spray?

No, treatment of suspected opioid overdose must be performed by someone other than the affected person. If you have or are prescribed NARCAN® Nasal Spray, it’s important to tell family, roommates, caregivers, friends and others around you where you keep NARCAN® Nasal Spray (at home, on your person, in your car, etc.) and how and when to use it. Also, inform them that NARCAN® Nasal Spray should always be given in accordance with the Instructions for Use, which are included in the package.

How does NARCAN® Nasal Spray work?

NARCAN® Nasal Spray is administered in the nostril and does not require evidence of breathing through the nose during administration.

When someone takes an overdose of opioids, the opiates overwhelm certain areas in the brain and interrupt a key part of the body’s impulse to breathe. Breathing slows dangerously or stops. Quickly rescuing this person is crucial because prolonged, severe breathing problems can lead to brain injury or death.

Naloxone, the active ingredient in NARCAN® Nasal Spray, competes with opioids to bind with the same receptors in the brain. Usually, it reverses the effects of opioid overdose in 2 to 3 minutes. This buys the opioid-poisoned person time for emergency medical help to arrive. If necessary, a bystander can give an additional dose of NARCAN® Nasal Spray if the patient doesn’t respond, doesn’t respond enough or relapses into breathing problems while awaiting additional help.

Get emergency medical help right away in any cases of known or suspected overdose emergency. NARCAN® Nasal Spray is not a substitute for emergency medical care. Administer in accordance with the Instructions for Use.

How long does NARCAN® Nasal Spray take to work?

If the patient does not respond in 2 to 3 minutes or responds and then relapses into respiratory depression, additional doses of NARCAN® Nasal Spray may be given every 2 to 3 minutes until emergency medical assistance arrives.

Each device is a single dose. If an additional dose is needed, you must use another device.

Get emergency medical help right away in any cases of known or suspected overdose emergency. NARCAN® Nasal Spray is not a substitute for emergency medical care. Administer in accordance with the Instructions for Use.

Can I reuse NARCAN® Nasal Spray?

No, you cannot reuse NARCAN® Nasal Spray. Each device is single-use, single-dose only. It is intended to be sprayed once, in a nostril, and then discarded.

Is it possible to use only half the contents?

No, the device is designed and FDA-approved to provide a single 4 mg dose of naloxone. It is intended to be sprayed once, in a nostril, and then discarded.

How long does NARCAN® Nasal Spray work? Will a second dose be needed?

NARCAN® Nasal Spray has been shown in studies to stay in the body for about 2 hours.

A second dose of NARCAN® Nasal Spray may be necessary. One dose of naloxone may not be enough to reverse the effects of an opioid overdose that involves strong opioids or more. Or, sometimes, the naloxone dose can wear off before the opioids—necessitating another dose.

Emergency medical services (EMS) will have been called immediately and will hopefully arrive before a second dose is needed. But if help hasn’t arrived, bystanders can administer additional doses of NARCAN® Nasal Spray every 2 to 3 minutes in alternating nostrils if the patient doesn’t respond, responds insufficiently or relapses back into respiratory depression.

Get emergency medical help right away in any cases of known or suspected overdose emergency. NARCAN® Nasal Spray is not a substitute for emergency medical care. Administer in accordance with the Instructions for Use.

What should I tell my healthcare provider before using NARCAN® Nasal Spray?

Before using NARCAN® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

  • Have heart problems.
  • Are pregnant or plan to become pregnant. Use of NARCAN® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use NARCAN® Nasal Spray.
  • Are breastfeeding or plan to breastfeed. It is not known if NARCAN® Nasal Spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How do you administer NARCAN® Nasal Spray?

Key steps to administering NARCAN® Nasal Spray:

  • PEEL back the package to remove the device. Hold the device with your thumb on the bottom of the plunger and 2 fingers on the nozzle.
  • PLACE the tip of the nozzle in either nostril until your fingers touch the bottom of the patient’s nose.
  • PRESS the plunger firmly to release the dose into the patient’s nose.

Remove the device from the nostril and, if you haven’t already done so, get emergency help right away. Continue to watch the patient. Most respond within 2 to 3 minutes.

If help hasn't arrived yet and the patient is not responding after 2 to 3 minutes, or responds and then relapses back into respiratory depression, give another dose. Make sure to use another device, as each device contains only one dose.

Get emergency medical help right away in any cases of known or suspected overdose emergency. NARCAN® Nasal Spray is not a substitute for emergency medical care. Administer in accordance with the Instructions for Use.

These steps are not comprehensive. See the Instructions for Use for more information. Administer in accordance with the Instructions for Use.

Is NARCAN® Nasal Spray addictive?

No, naloxone has no potential for abuse or overdose. It does not work in the absence of opioids.

What are the possible side effects of NARCAN® Nasal Spray?

NARCAN® Nasal Spray may cause serious side effects, including sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving NARCAN® Nasal Spray and may include:

  • Body aches
  • Diarrhea
  • Increased heart rate
  • Fever
  • Runny nose
  • Sneezing
  • Goose bumps
  • Sweating
  • Nausea or vomiting
  • Nervousness
  • Restlessness or irritability, shivering or trembling
  • Stomach cramping
  • Weakness
  • Increased blood pressure

In infants less than 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

View Full Prescribing Information.

What are the ingredients in NARCAN® Nasal Spray?

Active ingredient: naloxone hydrochloride

Inactive ingredients: benzalkonium chloride (preservative), disodium ethylenediametetraacetate (stabilizer), sodium chloride, hydrochloric acid to adjust pH and sterile water

NARCAN® Nasal Spray is not made with natural rubber latex.

How should I store NARCAN® Nasal Spray?
  • Store NARCAN® Nasal Spray at room temperature between 59°F to 77°F (15°C to 25°C). NARCAN® Nasal Spray may be stored for short periods up to 104°F (40°C)
  • Do not freeze NARCAN® Nasal Spray
  • Keep the NARCAN® Nasal Spray in its box until ready to use. Protect from light
  • Replace NARCAN® Nasal Spray before the expiration date on the box
  • Keep NARCAN® Nasal Spray and all medicines out of the reach of children
How do I buy NARCAN® Nasal Spray?

NARCAN® Nasal Spray is a prescription product. Talk to your doctor about how to obtain NARCAN® Nasal Spray.

Where do I go to buy NARCAN® Nasal Spray?

In most states, a prescription from a physician is required in order to obtain NARCAN® Nasal Spray. If you use an opioid, talk to your doctor about how to obtain NARCAN® Nasal Spray.

NOTE: There are a number of states that do not require a physician’s prescription to obtain NARCAN® Nasal Spray. In these states, pharmacists can provide an individualized prescription directly to residents. This is called “direct dispensing.”

To find out if your state is a direct dispense state, please click here.



For Healthcare Professionals

What pharmacokinetic data is there to support the use of NARCAN® Nasal Spray?

In a pharmacokinetic study in 30 healthy adult subjects, the relative bioavailability (BA) of one nasal spray in one nostril (4 mg total dose, 0.1 mL of 40 mg/mL naloxone hydrochloride solution) and two nasal sprays administered as one nasal spray in each nostril (8 mg total dose, 0.1 mL of 40 mg/mL naloxone hydrochloride solution in each nostril) was compared to a single dose of 0.4 mg naloxone hydrochloride intramuscular injection.

The pharmacokinetic parameters obtained in the study are as follows:

Parameter

4 mg – One Nasal Spray in one nostril

8 mg – Two Nasal Sprays, one in each nostril

0.4 mg Intramuscular Injection

 

(N=29)

(N=29)

(N=29)

tmax (h)*

0.50 (0.17, 1.00)

0.33 (0.17, 1.00)

0.38 (0.08, 2.05)

Cmax (ng/mL)

4.83 (43.1)

9.70 (36.0)

0.88 (30.5)

AUCt (hr.ng/mL)

7.87 (37.4)

15.3 (23.0)

1.72 (22.9)

AUC0-inf (h*ng/mL)

7.95 (37.3)

15.5 (22.7)

1.76 (22.6)

t1/2 (h)

2.08 (29.5)

2.10 (32.4)

1.24 (25.9)


*tmax reported as median (minimum, maximum)

Why the 4 mg dose?

The 4 mg dose in NARCAN® Nasal Spray was selected based on results from studies conducted in collaboration with the National Institute on Drug Abuse (NIDA). In clinical trials conducted to support the approval of NARCAN® Nasal Spray, administration of the drug in one nostril delivered approximately the same levels or higher of naloxone as a single dose of an FDA-approved naloxone intramuscular injection, and achieved these levels in approximately the same time frame.

How can I order NARCAN® Nasal Spray?

First responder organizations (EMS, law enforcement and fire departments) and community-based naloxone distribution programs will be able to get NARCAN® Nasal Spray from authorized wholesalers, distributors and pharmacies.

Order forms can be downloaded here.

Additionally, ADAPT Pharma, the maker of this medication, has a dedicated customer service team to help group purchasers source NARCAN® Nasal Spray and place an order.

Contact the customer service team at: 1-844-4-NARCAN (844) 462-7226 or customerservice@adaptpharma.com.

Can NARCAN® Nasal Spray be used on a child?

The safety and effectiveness of NARCAN® Nasal Spray has been established in pediatric patients for known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. Use of naloxone hydrochloride in pediatric patients is supported by evidence from adequate and well-controlled studies of naloxone hydrochloride in adults with additional data from 15 clinical studies (controlled and uncontrolled) in which neonates and pediatric patients received parenteral naloxone hydrochloride in doses ranging from 0.005 mg/kg to 0.01 mg/kg. Safety and effectiveness are also supported by use of other naloxone hydrochloride products in the post-marketing setting, as well as data available in the medical literature and clinical practice guidelines. NARCAN® Nasal Spray may be administered to pediatric patients of all ages.

Absorption of naloxone hydrochloride following intranasal administration in pediatric patients may be erratic or delayed. Even when the opiate-intoxicated pediatric patient responds appropriately to naloxone hydrochloride, he/she must be carefully monitored for at least 24 hours, as a relapse may occur as naloxone hydrochloride is metabolized. In opioid-dependent pediatric patients (including neonates), administration of naloxone hydrochloride may result in an abrupt and complete reversal of opioid effects, precipitating an acute opioid withdrawal syndrome. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life threatening, if not recognized, and should be treated according to protocols developed by neonatology experts.

In settings such as in neonates with known or suspected exposure to maternal opioid use, where it may be preferable to avoid the abrupt precipitation of opioid withdrawal symptoms, consider use of an alternate naloxone-containing product that can be dosed according to weight and titrated to effect.

Also, in situations where the primary concern is for infants at risk for opioid overdose, consider whether the availability of alternate naloxone-containing products may be better suited than NARCAN® Nasal Spray.

What are the side effects associated with the use of NARCAN® Nasal Spray?

The following adverse reactions were observed in a clinical study of NARCAN® Nasal Spray:

  • Increased blood pressure
  • Musculoskeletal pain
  • Headache
  • Nasal dryness
  • Nasal edema
  • Nasal congestion
  • Nasal inflammation

Adverse reactions have been identified during post-approval use of naloxone hydrochloride in the postoperative setting:

  • Hypotension
  • Hypertension
  • Ventricular tachycardia and fibrillation
  • Dyspnea
  • Pulmonary edema
  • Cardiac arrest

Death, coma and encephalopathy have been reported as sequelae of these events. Excessive doses of naloxone hydrochloride in postoperative patients have resulted in significant reversal of analgesia and have caused agitation.

Abrupt reversal of opioid effects in persons who were physically dependent on opioids has precipitated signs and symptoms of opioid withdrawal including:

  • Body aches
  • Fever
  • Sweating
  • Runny nose
  • Sneezing
  • Piloerection
  • Yawning
  • Weakness
  • Shivering or trembling
  • Nervousness
  • Restlessness or irritability
  • Diarrhea, nausea or vomiting
  • Abdominal cramps
  • Increased blood pressure
  • Tachycardia

In the neonate, opioid withdrawal signs and symptoms also included:

  • Convulsions
  • Excessive crying
  • Hyperactive reflexes
Are there any contraindications?

Patients should not use NARCAN® Nasal Spray if they are allergic to naloxone hydrochloride or any other ingredients:

  • Benzalkonium chloride (preservative)
  • Disodium ethylenediaminetetraacetate (stabilizer)
  • Sodium chloride
  • Hydrochloric acid (to adjust pH)
  • Purified water
Are there any other safety considerations concerning the use of NARCAN® Nasal Spray?

Click here to view the Important Safety Information

REFERENCE: 1. NARCAN® Nasal Spray 4 mg [package insert]. Radnor, PA: Adapt Pharma; 2016.

INDICATIONS AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up.

NARCAN® Nasal Spray is safe and effective in children for known or suspected opioid overdose.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines. Always carry NARCAN® Nasal Spray with you in case of an opioid emergency.

  1. Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:
    • unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • the black circle in the center of the colored part of the eye (pupil) is very small, sometimes called "pinpoint pupils" in someone difficult to awaken
  2. Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® Nasal Spray before an opioid emergency happens.
  3. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.
  4. The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person until emergency help is received.

Who should not use NARCAN® Nasal Spray?

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What should I tell my healthcare provider before using NARCAN® Nasal Spray?

Before using NARCAN® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • are pregnant or plan to become pregnant. Use of NARCAN® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use NARCAN® Nasal Spray.
  • are breastfeeding or plan to breastfeed. It is not known if NARCAN® Nasal Spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NARCAN® Nasal Spray?

NARCAN® Nasal Spray may cause serious side effects, including:
Sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving NARCAN® Nasal Spray and may include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increase blood pressure.

In infants under 4-weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.

The risk information provided here is not comprehensive. To learn more, talk about NARCAN® Nasal Spray with your health care provider or pharmacist. The FDA-approved product labeling can be found here or 1-844-4NARCAN (1-844-462-7226).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including the Patient Information, for NARCAN® Nasal Spray.

References
** IMS Health, NPA Extended Insights Audit, YTD March 2017

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INDICATIONS AND IMPORTANT SAFETY INFORMATION
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