NARCAN® Nasal Spray cost $37.50 per 4 mg dose ($75 per carton) for all qualified direct purchasers

What is Narcan®
NASAL SPRAY?

NARCAN® Nasal Spray is the first and only FDA-approved nasal form of naloxone that was developed in partnership with the National Institute of Drug Abuse (NIDA) for the emergency treatment of a known or suspected opioid overdose.1

According to the Centers for Disease Control and Prevention (CDC), there is an "epidemic of opioid addiction in the U.S."2 In 2016, the United Nations Office of Drugs and Crime concluded that there was more opioid use in the U.S. than anywhere else in the world.3

Given that opioid overdose deaths occur outside of a medical setting 75% of the time,4 there is a good chance you may be first to respond to an opioid overdose emergency.

In the last several years, U.S. law enforcement has seen a dramatic increase in the availability of dangerous synthetic opioids, including fentanyl. The presence of these synthetic opioids in the illicit U.S. drug market is extremely concerning, as the potency of these drugs has led to a significant increase in overdose incidents and overdose-related deaths throughout the nation.5 This landscape is so concerning that the DEA has issued the DEA Briefing Guide for First Responders as a warning to all first responders.5

From the drug enforcement agency:

"There is a significant threat to law enforcement personnel, and other first responders, who may come in contact with fentanyl and other fentanyl-related substances through routine law enforcement, emergency or life-saving activities. Since fentanyl can be ingested orally, inhaled through the nose or mouth, or absorbed through the skin or eyes, any substance suspected to contain fentanyl should be treated with extreme caution, as exposure to a small amount can lead to significant health-related complications, respiratory depression, or death."5

For many law enforcement agencies, the impetus to carry naloxone often centers on treatment of people who overdose. However, an important aspect of the carrying of naloxone is to treat the members of the force who may accidentally be exposed to synthetic opioids such as fentanyl and carfentanil. Fentanyl and fentanyl analogues can be up to 100 times more powerful than morphine and 30-50 times more powerful than heroin.6

NARCAN® Nasal Spray is a prescription medicine that helps to reverse the life-threatening effects of opioid overdose or a possible opioid overdose, with signs of breathing problems and severe sleepiness or not being able to respond.1

The appropriate use of NARCAN® Nasal Spray may help law enforcement officers, emergency medical technicians, or corrections officers temporarily reverse the effects of a known or suspected opioid overdose. However, NARCAN® Nasal Spray is not a substitute for emergency medical care. Repeated doses may be necessary, and it is important to the keep patient under surveillance as symptoms may return. Results may vary.

Benefits of NARCAN® Nasal Spray

NARCAN® Nasal Spray helps reverse an opioid overdose.

  • Concentrated 4 mg dose1
  • Needle-free; no assembly required1
  • Designed for ease-of-use in the community setting1
  • Requires no specialized training*1

Key steps to administering NARCAN® NASAL SPRAY*

PEEL

Peel back the package to remove the device. Hold the device with your thumb on the bottom of the plunger and 2 fingers on the nozzle.

PLACE

Place and hold the tip of the nozzle in either nostril until your fingers touch the bottom of the patient's nose.

PRESS

Press the plunger firmly to release the dose into the patient's nose.

*Administer in accordance with the Instructions for Use. Please refer to the Quick Start Guide.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® (naloxone HCl) Nasal Spray is used for the treatment of an opioid emergency or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up because symptoms may return. Repeat doses may be necessary.

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines.

Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death.

Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® before an opioid emergency happens.

Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray.

Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.

The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person closely until emergency help is received.

NARCAN® Nasal Spray may cause serious side effects, including sudden opioid withdrawal symptoms.

Opioid withdrawal symptoms may include body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increased blood pressure.

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.
To report SUSPECTED ADVERSE REACTIONS, contact ADAPT Pharma, Inc. at 1-844-4NARCAN (1-844-462-7226) or FDA at 1-800-FDA-1088 or
www.fda.gov/medwatch.

Please see full Prescribing Information.

References: 1. NARCAN® Nasal Spray. Prescribing Information. Adapt Pharma, Inc. Radnor, PA; 2017. 2. Centers for Disease Control and Prevention. Vital Signs—Prescription Painkiller Overdoses in the US. Available at: https://www.cdc.gov/vitalsigns/painkilleroverdoses/index.html. Accessed August 2018. 3. United Nations Office on Drugs and Crime. Annual Prevalence of Drug Use. Available at: https://dataunodc.un.org/drugs/prevalence_table. Accessed August 2018. 4. Surgeon General's Advisory on Naloxone and Opioid Overdose. U.S. Department of Health and Human Services. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxone-advisory.html. Accessed May 2018. 5. US Department of Justice, Drug Enforcement Administration. A Briefing Guide for First Responders. 6. Drug Enforcement Administration. DEA issues nationwide alert on fentanyl as threat to health and public safety. Available at: https://www.dea.gov/press-releases/2015/03/18/dea-issues-nationwide-alert-fentanyl-threat-health-and-public-safety. Accessed August 2018. 7. PoliceOne. White paper: Building an opioid overdose reversal program. Availabe at: https://www.policeone.com/police-products/medical-supplies/articles/212042006-White-paper-Building-an-Opioid-Overdose-Reversal-Program/. Accessed August 2018.

INDICATION AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® (naloxone HCl) Nasal Spray is used for the treatment of an opioid emergency or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond. NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up because symptoms may return. Repeat doses may be necessary.

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines.

Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death.

Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® before an opioid emergency happens.

Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray.

Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.

The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person closely until emergency help is received.

NARCAN® Nasal Spray may cause serious side effects, including sudden opioid withdrawal symptoms.

Opioid withdrawal symptoms may include body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increased blood pressure.

In infants under 4 weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.
To report SUSPECTED ADVERSE REACTIONS, contact ADAPT Pharma, Inc. at 1-844-4NARCAN (1-844-462-7226) or FDA at 1-800-FDA-1088 or
www.fda.gov/medwatch.

Please see full Prescribing Information.

References: 1. NARCAN® Nasal Spray. Prescribing Information. Adapt Pharma, Inc. Radnor, PA; 2017. 2. Centers for Disease Control and Prevention. Vital Signs—Prescription Painkiller Overdoses in the US. Available at: https://www.cdc.gov/vitalsigns/painkilleroverdoses/index.html. Accessed August 2018. 3. United Nations Office on Drugs and Crime. Annual Prevalence of Drug Use. Available at: https://dataunodc.un.org/drugs/prevalence_table. Accessed August 2018. 4. Surgeon General's Advisory on Naloxone and Opioid Overdose. U.S. Department of Health and Human Services. https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxone-advisory.html. Accessed May 2018. 5. US Department of Justice, Drug Enforcement Administration. A Briefing Guide for First Responders. 6. Drug Enforcement Administration. DEA issues nationwide alert on fentanyl as threat to health and public safety. Available at: https://www.dea.gov/press-releases/2015/03/18/dea-issues-nationwide-alert-fentanyl-threat-health-and-public-safety. Accessed August 2018. 7. PoliceOne. White paper: Building an opioid overdose reversal program. Availabe at: https://www.policeone.com/police-products/medical-supplies/articles/212042006-White-paper-Building-an-Opioid-Overdose-Reversal-Program/. Accessed August 2018.