Find NARCAN® Nasal Spray

INDICATIONS AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up.

NARCAN® Nasal Spray is safe and effective in children for known or suspected opioid overdose.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines. Always carry NARCAN® Nasal Spray with you in case of an opioid emergency.

  1. Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:
    • unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • the black circle in the center of the colored part of the eye (pupil) is very small, sometimes called "pinpoint pupils" in someone difficult to awaken
  2. Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® Nasal Spray before an opioid emergency happens.
  3. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.
  4. The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person until emergency help is received.

Who should not use NARCAN® Nasal Spray?

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What should I tell my healthcare provider before using NARCAN® Nasal Spray?

Before using NARCAN® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • are pregnant or plan to become pregnant. Use of NARCAN® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use NARCAN® Nasal Spray.
  • are breastfeeding or plan to breastfeed. It is not known if NARCAN® Nasal Spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NARCAN® Nasal Spray?

NARCAN® Nasal Spray may cause serious side effects, including:
Sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving NARCAN® Nasal Spray and may include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increase blood pressure.

In infants under 4-weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.

The risk information provided here is not comprehensive. To learn more, talk about NARCAN® Nasal Spray with your health care provider or pharmacist. The FDA-approved product labeling can be found here or 1-844-4NARCAN (1-844-462-7226).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including the Patient Information, for NARCAN® Nasal Spray.

View All

Presented for educational background only. No claims are made for any effect of NARCAN® Nasal Spray on the opioid overdose crisis described below.
 

THE OPIOID OVERDOSE CRISIS

Many people take opioids to manage their pain. In fact, more than 260 million opioid prescriptions are filled in the US each year. The most commonly misused prescription opioids are methadone, oxycodone, hydrocodone, and fentanyl.

According to the United States Centers for Disease Control and Prevention (CDC), overdoses from prescription painkillers and heroin use are significant and growing public health problems.


narcan-car

In 2014, opioid overdose deaths occurred at an average rate of 1 every 17 minutes.

narcan-car

Overdose now surpasses car crashes as the leading cause of accidental death in the US.


  • Nearly 80 people will die today from a potentially preventable, opioid-related overdose
  • Overdose now surpasses car crashes as the leading cause of accidental death in the US. Two-thirds of those deaths involve prescription opioids.
  • Prescription opioid overdose-related deaths claimed 18,893 lives in the United States in 2014
  • There were 10,574 heroin overdose-related deaths in 2014, an increase of 600% from 2001
  • In 2013, approximately 77% of opioid overdose-related deaths happened outside medical settings, with the majority (56%) happening in homes

A NATIONAL Crisis—Opioid overdose deaths

The graph below displays US Opioid Overdose Deaths from 2000 through 2014. While there was a drop in prescription opioid deaths in 2012, since 2013, overdose deaths due to prescription opioids and heroin have both continued to rise, with a steep rise in heroin-related deaths helping to drive a corresponding rise in overall deaths.


SOURCE: Centers for Disease Control and Prevention. Increases in Drug and Opioid Overdose Deaths - United States, 2000-2014. MMWR 2015. http://www.cdc.gov/drugoverdose

Risk of Accidental Overdose from Opioids

Anyone who uses prescription opioids to manage long-term pain, or who uses heroin, may be at risk of experiencing an accidental, life-threatening or deadly opioid overdose from the misuse of those products. Accidental opioid overdoses can occur anytime and anywhere across the nation, from cities to rural counties and suburban neighborhoods.

narcan-car

Most accidental opioid overdoses occur in people’s homes.

People at higher risk of opioid overdose*

People who:

  • use prescription opioids, especially those taking higher doses
  • use opioids in combination with other sedating substances
  • use opioids and have medical conditions such as HIV or liver or lung disease, or who suffer from depression
  • inject opioids

People with:

  • household members in possession of opioids
  • opioid dependence and reduced tolerance following detoxification, release from incarceration, or cessation of treatment
  • a suspected or confirmed history of substance abuse, dependence or non-medical use of prescription or illegal opioids

*Adapted from World Health Organization, 2013.

Opioids are a powerful class of drugs that include:

Prescription medication pain relievers

Illegal drugs

Hydrocodone (e.g., Vicodin®, Lortab®)

Oxycodone (e.g., OxyContin®, Percocet®)

Codeine

Morphine

Hydromorphone (e.g., Dilaudid®, Exalgo®)

Fentanyl (e.g., Duragesic®, Fentora®)

Methadone

Oxymorphone (e.g., Opana® ER)

Heroin

Fentanyl made or sold by unauthorized parties

INDICATIONS AND IMPORTANT SAFETY INFORMATION

What is NARCAN® (naloxone HCl) Nasal Spray?

NARCAN® Nasal Spray is a prescription medicine used for the treatment of an opioid emergency such as an overdose or a possible opioid overdose with signs of breathing problems and severe sleepiness or not being able to respond.

NARCAN® Nasal Spray is to be given right away and does not take the place of emergency medical care. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray, even if the person wakes up.

NARCAN® Nasal Spray is safe and effective in children for known or suspected opioid overdose.

What is the most important information I should know about NARCAN® Nasal Spray?

NARCAN® Nasal Spray is used to temporarily reverse the effects of opioid medicines. The medicine in NARCAN® Nasal Spray has no effect in people who are not taking opioid medicines. Always carry NARCAN® Nasal Spray with you in case of an opioid emergency.

  1. Use NARCAN® Nasal Spray right away if you or your caregiver think signs or symptoms of an opioid emergency are present, even if you are not sure, because an opioid emergency can cause severe injury or death. Signs and symptoms of an opioid emergency may include:
    • unusual sleepiness and you are not able to awaken the person with a loud voice or by rubbing firmly on the middle of their chest (sternum)
    • breathing problems including slow or shallow breathing in someone difficult to awaken or who looks like they are not breathing
    • the black circle in the center of the colored part of the eye (pupil) is very small, sometimes called "pinpoint pupils" in someone difficult to awaken
  2. Family members, caregivers, or other people who may have to use NARCAN® Nasal Spray in an opioid emergency should know where NARCAN® Nasal Spray is stored and how to give NARCAN® Nasal Spray before an opioid emergency happens.
  3. Get emergency medical help right away after giving the first dose of NARCAN® Nasal Spray. Rescue breathing or CPR (cardiopulmonary resuscitation) may be given while waiting for emergency medical help.
  4. The signs and symptoms of an opioid emergency can return after NARCAN® Nasal Spray is given. If this happens, give another dose after 2 to 3 minutes using a new NARCAN® Nasal Spray and watch the person until emergency help is received.

Who should not use NARCAN® Nasal Spray?

Do not use NARCAN® Nasal Spray if you are allergic to naloxone hydrochloride or any of the ingredients in NARCAN® Nasal Spray.

What should I tell my healthcare provider before using NARCAN® Nasal Spray?

Before using NARCAN® Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you:

  • have heart problems
  • are pregnant or plan to become pregnant. Use of NARCAN® Nasal Spray may cause withdrawal symptoms in your unborn baby. Your unborn baby should be examined by a healthcare provider right away after you use NARCAN® Nasal Spray.
  • are breastfeeding or plan to breastfeed. It is not known if NARCAN® Nasal Spray passes into your breast milk.

Tell your healthcare provider about the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of NARCAN® Nasal Spray?

NARCAN® Nasal Spray may cause serious side effects, including:
Sudden opioid withdrawal symptoms. In someone who has been using opioids regularly, opioid withdrawal symptoms can happen suddenly after receiving NARCAN® Nasal Spray and may include: body aches, diarrhea, increased heart rate, fever, runny nose, sneezing, goose bumps, sweating, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, stomach cramping, weakness, increase blood pressure.

In infants under 4-weeks old who have been receiving opioids regularly, sudden opioid withdrawal may be life-threatening if not treated the right way. Signs and symptoms include: seizures, crying more than usual, and increased reflexes.

These are not all of the possible side effects of NARCAN® Nasal Spray. Call your doctor for medical advice about side effects.

The risk information provided here is not comprehensive. To learn more, talk about NARCAN® Nasal Spray with your health care provider or pharmacist. The FDA-approved product labeling can be found here or 1-844-4NARCAN (1-844-462-7226).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including the Patient Information, for NARCAN® Nasal Spray.

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© 2016 ADAPT Pharma, Inc. NARCAN® is a registered trademark licensed to ADAPT Pharma Operations Limited. NAR4-69-16.

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INDICATIONS AND IMPORTANT SAFETY INFORMATION
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